Retraction for Geraghty et al., Detecting patterns of protein distribution and gene expression in silico, PNAS 1999 96:2937-2942
نویسندگان
چکیده
منابع مشابه
Detecting patterns of protein distribution and gene expression in silico.
Most biological information is contained within gene and genome sequences. However, current methods for analyzing these data are limited primarily to the prediction of coding regions and identification of sequence similarities. We have developed a computer algorithm, CoSMoS (for context sensitive motif searches), which adds context sensitivity to sequence motif searches. CoSMoS was challenged t...
متن کاملRetraction for Dougan et al., Probing osmolyte participation in the unfolding transition state of a protein.
Understanding the molecular mechanisms of osmolyte protection in protein stability has proved to be challenging. In particular, little is known about the role of osmolytes in the structure of the unfolding transition state of a protein, the main determinant of its dynamics. We have developed an experimental protocol to directly probe the transition state of a protein in a range of osmolyte envi...
متن کاملSood Et Al. Cell-type-specific Signatures of Micrornas on Target Mrna Expression. Pnas
MicroRNA(miRNA) plays an important role in gene regulation, affecting biological processes such as cell differentiation, proliferation, and apoptosis. It has been shown that miRNA’s carry out gene regulation by decreasing the steady-state levels of their target mRNA’s. In an attempt to further address the functional role of miRNA, the authors of this paper used existing microarray data to analy...
متن کاملRetraction for Dougan et al., Solvent molecules bridge the mechanical unfolding transition state of a protein.
We demonstrate a combination of single molecule force spectroscopy and solvent substitution that captures the presence of solvent molecules in the transition state structure. We measure the effect of solvent substitution on the rate of unfolding of the I27 titin module, placed under a constant stretching force. From the force dependency of the unfolding rate, we determine Deltax(u), the distanc...
متن کاملRetraction: Sebeo et al., Requirement for protein synthesis at developing synapses.
The article “Requirement for Protein Synthesis at Developing Synapses” by Joseph Sebeo, Kuangfu Hsiao, Ozlem Bozdagi, Dani Dumitriu, Yongchao Ge, Qiang Zhou, and Deanna L. Benson, which appeared on pages 9778 –9793 of the August 5, 2009 issue has been retracted by the authors, who report the following: “It has come to our attention that there were serious irregularities with some of the Western...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2004
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0407487101